RUC-1 protects hαIIb/mβ3 mice from cremaster arteriole thrombus formation. Mice expressing hαIIb/mβ3 were injected with DMSO (control) or RUC-1 (26.5 mg/kg) intraperitoneally 25 to 30 minutes before laser injury. Five minutes before injury, mice were injected intravenously with antibodies to GPIbβ (green) or fibrin (red). (A) Images were obtained 2.5 minutes after surgery. The videos for DMSO and RUC-1 are available as supplemental Video 1 and supplemental Video 2, respectively. (B) Average platelet (left) and fibrin accumulation (right) for the 9 injuries (3 mice per arm with 3 injuries per mouse).