Kinetics of therapy response compared in NPM1⁺/FLT3-LM⁻/FLT3-TKD⁻, NPM1⁺/FLT3-LM⁺/FLT3-TKD⁻, and NPM1⁺/FLT3-LM⁻/FLT3-TKD⁺ AML patients. Boxes represent the 50th percentile, red lines the 25th percentiles, and black bars the median of each group. These data show very similar kinetics in all 3 subgroups. Only the higher levels of the NPM1⁺/FLT3-LM⁺ between days 121 and 365 reflect the greater relapse rate in this group compared with the other 2 groups.