Odds ratio of association of imaging parameters with baseline laboratory and imaging features. Plotted are the log odds ratio values with 95% confidence interval values for 5 imaging parameters (PET-FL, FDG-avid focal lesion number; MRI-FL, MRI-defined focal lesion number, MBS-OL, metastatic bone survey-defined osteolytic lesion number; SUV-FL, maximum standardized uptake values at bone marrow focal lesion sites; CT-OL, computed tomography–defined osteolytic lesion number). Significant correlations were observed for most imaging parameters with B2M, LDH, and several GEP-derived parameters such as high-risk, LB disease and proliferation (PR) subgroups, and proliferation index (PI).