Untreated myeloma patient with time-concordant MBS, MRI, and FDG-PET/CT studies. Baseline imaging studies (top row) showed no osteolysis on MBS (top left), several foci on STIR-weighted MRI images with the largest in the left ischium (top middle), and 2 foci on FDG-PET/CT imaging (top right) with the largest again in the left ischium with a maximum SUV of 4.1. The patient was in near-complete remission 168 days later, with a significant decrease in focal activity in the left ischial lesion on PET (bottom right).