American Society of Hematology

Figure 6

$Figure 6. TCR-stimulated LFA-1–dependent adhesion to ICAM-1 is abrogated only in LAD-III T cells deficient in both Kindlin-3 and CDGI. T cells from the indicated LAD-III patients and control donors were settled for 1 minute on identical ICAM-1-Fc–coated surfaces in the absence or the presence of anti-CD3 mAb (OKT3, 10 μg/mL), and the fractions of initially settled T cells that resisted detachment to a shear stress of 1 dyn/cm2 were each scored in 2 fields of view. Results shown are representative of 2 independent experiments.$

TCR-stimulated LFA-1–dependent adhesion to ICAM-1 is abrogated only in LAD-III T cells deficient in both Kindlin-3 and CDGI. T cells from the indicated LAD-III patients and control donors were settled for 1 minute on identical ICAM-1-Fc–coated surfaces in the absence or the presence of anti-CD3 mAb (OKT3, 10 μg/mL), and the fractions of initially settled T cells that resisted detachment to a shear stress of 1 dyn/cm² were each scored in 2 fields of view. Results shown are representative of 2 independent experiments.

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