Phenotype of NR4A1^+/−NR4A3^−/− and NR4A1^−/−NR4A3^+/− mice. (A) Kaplan-Meier curve shows survival of NR4A1^+/−NR4A3^−/− (n = 38) and NR4A1^−/−NR4A3^+/− (n = 115) mice compared with wild-type control mice (n = 10). (B) Massive splenomegaly in diseased mouse (left) compared with age-matched control (right). Image shown represents an 18-fold difference in weight. Scale bar represents 1 cm. (C) Quantification of hepatomegaly (left) and splenomegaly (right) in hypoallelic mice (○, n = 18 for liver and n = 23 for spleen) compared with healthy littermates (●, n = 8 for liver and n = 9 for spleen). Horizontal bars represent the mean. *P = .001. Both NR4A1^−/−NR4A3^+/− and NR4A1^+/−NR4A3^−/− mice were used for this assay; analysis was conducted when animals were moribund.