Genes with differential expression between normal (BMPC) and malignant plasma cells (MMC) as determined by EB statistics and Benjamini-Hochberg correction for multiple testing of genes expressed at least once in the training and validation group. (Ai) Proangiogenic and (Aii) antiangiogenic genes. (Bi) Proangiogenic and (Bi) anti-angiogenic genes differentially expressed between early-stage (MGUS + MMI) and late-stage (MMII + MMIII) myeloma. (Ci) Proangiogenic and (Cii) antiangiogenic genes differentially expressed between BMPC and MGUS.