Monitoring scenarios. The “a” curve shows a patient in a CCyR, but without a MMR, with a rising BCR-ABL. This is a worrisome case that demands close follow-up (Figure 3). Curve “b” show a patient with a CCyR and a MMR, with a rising BCR-ABL. This case requires follow-up, but not necessarily major concern, unless the rise continues, especially with a resistant mutation. Lastly, curve “c” shows a luck patient with the best of circumstances: a CCyR, MMR, and a stable or declining BCR-ABL. Professional illustration by Marie Dauenheimer.