Mutations in GATA zinc finger domain. GATA zinc finger domains bind DNA in 2 conformations the adjacent and opposite forms. Here, we use the adjacent structure (3DFV).¹⁰  (A) Illustrated view of single GATA zinc finger (green) bound to DNA with adjacent GATA molecule in gray. R398 (cyan), T354 (magenta), and zinc ion (yellow) shown in space filling representation. (B) Wild-type R398 shown inserting into minor groove and possible H bonds with DNA bases. (C) R398W mutation modeled. (D) Wild-type T354. (E) T354M mutation modeled showing increased side chain size.