TRV in m/s. Left, adults > 18 years of age with thalassemia (n = 103); right, children with thalassemia < 18 years of age (n = 45). Filled circles represent patients with a TRV ≥ 2.5 m/s; filled black circles reflect patients with a TRV ≥ 3.0 m/s, and filled gray circles represent patients with a TRV between 2.5 and 2.9 m/s. Unfilled circles represent patients with a TRV < 2.5 m/s.