MSI2 expression levels associated with outcome. Representative cores are shown for percentage MSI2 positivity below (A), at (B), or above (C) the 75th centile, illustrating the relatively low abundance of positive cells associated with poorer outcome (B-C). For each core, the entire core is shown (original magnification ×40) and a representative inset below (original magnification ×200). Micrographs were imaged using a Nikon Eclipse 80i microscope and captured using a Nikon DS-F digital camera with NIS-Elements D 3.1 software, with manipulation in CorelDRAW X3. For each core the entire core was imaged using a Nikon Fluor Apo 4×/0.13 air objective and a representative high power image with a Nikon Plan Apor 20×/0.75 air objective.