Differences in HRQOL between baseline and follow-up. (A-C) Differences in global health status (GH) as well as 5 functioning scales [physical functioning (PF), role functioning (RF), emotional functioning (EF), cognitive functioning (CF), social functioning (SF)] and fatigue between baseline and month 6 (A), baseline and month 12 (B), as well as baseline and month 24 (C). Differences in linear analog scales (Δ) of mean HRQOL values for chlorambucil- versus fludarabine-treated patients between baseline and month 6 (Figure 6A), baseline and month 12 (Figure 6B), and baseline and month 24 (Figure 6C). marks a significant difference between the Δ of mean scores. Baseline questionnaire and follow-up questionnaires were available in 65 patients (28 for chlorambucil, 37 for fludarabine) at 6 months, 51 (27 for chlorambucil, 24 for fludarabine) at 12 months, and 24 (13 for chlorambucil, 11 for fludarabine) at 24 months.