Figure 6
Figure 6. Capitulation of C/ebpαDN-induced abnormalities in the Bmi1 transgenic embryos. (A-B) External features of the Tg(lmo2:LDL-EGFP) (A) and Tg(lmo2:LDL-Bmi1-EGFP) (B) embryos at 80 hpf. The circulation congestion is readily detected in the Bmi1-expressing embryos (B, arrowheads; and supplemental Videos 1 and 3). Black boxes with dashed lines indicate the regions amplified at the bottom. DA indicates dorsal aorta; and CV, caudal vein. (C-F) Proliferation and apoptosis analyses by pH3 immunochemistry stainings (C-D) and TUNEL assays (E-F) in the embryos expressing EGFP and Bmi1-EGFP at 80 hpf. (G-H) WISH analyses of αE1-globin in the transgenic embryos at 80 hpf. The star, red arrow, and arrowheads indicate the increased number of cells with expression of αE1-globin transcripts within the embryonic vasculatures.

Capitulation of C/ebpαDN-induced abnormalities in the Bmi1 transgenic embryos. (A-B) External features of the Tg(lmo2:LDL-EGFP) (A) and Tg(lmo2:LDL-Bmi1-EGFP) (B) embryos at 80 hpf. The circulation congestion is readily detected in the Bmi1-expressing embryos (B, arrowheads; and supplemental Videos 1 and 3). Black boxes with dashed lines indicate the regions amplified at the bottom. DA indicates dorsal aorta; and CV, caudal vein. (C-F) Proliferation and apoptosis analyses by pH3 immunochemistry stainings (C-D) and TUNEL assays (E-F) in the embryos expressing EGFP and Bmi1-EGFP at 80 hpf. (G-H) WISH analyses of αE1-globin in the transgenic embryos at 80 hpf. The star, red arrow, and arrowheads indicate the increased number of cells with expression of αE1-globin transcripts within the embryonic vasculatures.

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