Gene expression in sorted CMML monocytes. (A) Heatmap of 1803 genes differentially expressed between healthy donor (n = 6) and CMML-sorted monocytes (n = 36; fold-change > 2; P < .05) results from a supervised analysis based on Euclidian distances. Red lines indicate CMYB and CJUN genes. Unsupervised analysis had previously identified 2 groups of CMML patients: those with a “normal monocyte-like” (highlighted with a green line, n = 8) and those with an “abnormal” (the others, n = 24) signature. (B) Kaplan-Meier survival estimates of OS according to the “normal monocyte-like” compared with the “abnormal” signature.