High levels of MEF2C gene expression found in clusters of AML patients with high incidence of MLL. Shown are pairwise correlations of gene expression profiles between AML patients calculated by OmiViz software (Version 3.6) and viewed by HeatMapper, as previously described.³⁰  The cells in the visualization are colored by Pearson correlation coefficient values, with deeper colors indicating higher positive (red) or negative (blue) correlations. Histograms next to each tumor represent expression levels for the IRF8 or MEF2C probe sets (bars are proportional to the level of expression). Six of 16 clusters identified in the cohort of 285 AML patients on the basis of the unsupervised clustering results, and other parameters, such as clinical and molecular characteristics of the AML patients, are indicated.³⁰  These correspond to clusters with a high incidence of t(11q23) (percentage is indicated), French-American-British classifications for myelomonocytic (M4) or monocytic (M5) AML, or aberrant high EVI1 expression. Bar diagram represents the mean expression levels (± SE) of MEF2C for patient samples with known MLL gene rearrangements (MLL) compared with all other patient samples (other) or with that in the patients samples within the indicated clusters. Patient numbers are indicated. P values were determined by the Student t test: **P < .001, *P = .02 compared with patients with 11q23 [MLL] disruptions.