In vivo luciferase imaging and quantitative Ctns expression in Ctns^−/− mice treated with WT BMCs as a function of time. (A) BMCs isolated from luciferase transgenic mice were transplanted into lethally irradiated Ctns^−/− mice (top panel) and WT mice (bottom panel). These are representative pictures taken in live animals with the IVIS imaging system after luciferin injection at 2, 3, and 4 months. The luminescence signal intensities were quantified and are represented in the matching histograms. (B) Percentage of Ctns expression in Ctns^−/− mice treated with WT BMCs compared with WT mice. The results represent the number of Ctns gene copies determined by quantitative RT-PCR as a ratio of the results shown in Table 3 for BMC-treated Ctns^−/− mice divided by the results for WT control mice.