Skin biopsies of patients with NXG and NX. Touton giant cells (hematoxylin coloration; A) with positive staining for CD163 in immunohistochemistry in NXG (B). (C) Dermal infiltration by spumous cells. (D) Positive staining for CD163 in NX. Images were acquired with an Olympus Bx51 microscope (A, 20×/0.5; B, 20×/0.5; C, 5×/0.16; and D, 5×/0.16) in Axiocam MRc (Zeiss; Axiovision 4.8.2).