Beneficial effect of nicked β2GPI on thrombotic ischemia (hypothesis). (1) If thrombus is formed in the artery, up-regulation of fibrinolysis occurs and plasminogen is converted into plasmin. (2) Plasmin cleaves β2GPI into nicked β2GPI, whereas angiostatin is generated via autoproteolysis of plasminogen. (3) Nicked β2GPI binds angiostatin and attenuates its antiangiogenic property, resulting in promoted angiogenesis. tPA indicates tissue plasminogen activator.