pDCs up-regulate β7-integrin during SIV infection. (A) FACS plots depict the gating used and the proportion of β7-integrin+ pDCs (CD123+) and mDCs (CD11c+) at day 0 and day 9 PI from the same RM. FACS plots are an overlay of pDCs or mDCs (black) on the HLA-DR+ LIN− population (gray). (B) Kinetics of β7-integrin+ pDCs and mDCs in the blood of RM after intrarectal SIV infection. (C) Kinetics of β7-integrin+ pDCs in the blood of RM after intravenous SIV infection and ART. (D) Proportion of β7-integrin+ pDCs in the blood of healthy (HIV−) and HIV+ individuals. Human blood pDCs were defined as CD123^hi HLA-DR+ CD3− CD20− CD14− cells. (E) Proportion of β7-integrin+ pDCs in the blood of uninfected or SIV-infected SM.