Reproduction of findings in chemical model. (A) Glucosylceramide levels in untreated and CBE-treated normal hMSCs. (B) S1P levels in untreated and CBE-treated normal hMSCs. (C) Glucosylceramide levels in CBE-treated human and murine MSCs and 293T cells, expressed as molar ratios compared with untreated cells. (D) S1P levels in CBE-treated human and murine MSCs and 293T cells, expressed as molar ratios compared with untreated cells. (E) Scatter plot comparing log2 intensities of detected genes in arrays of untreated and CBE-treated hMSCs, to show the quality of the assay. (F) Relative mRNA levels of selected genes in CBE-treated normal MSCs compared with untreated normal MSCs. *P < .05. All error bars represent 1 SD.