Genomic profile of F-refractory CLL stratified by TP53 mutation. F-refractory CLL cases with (n = 37) and without (n = 62) TP53 mutation show a different hierarchical genetic profile. Cases with the 17p deletion are overrepresented in the mutation group (P < .001), whereas cases with the 11q deletion are overrepresented in the group without the TP53 mutation.