American Society of Hematology

Figure 3

$Figure 3. Functional assessment of p21/p53 induction after DNA damage may be normal in cases with F-refractory disease without the 17p deletion or TP53 mutation. (A) Normal p21 and p53 induction before and after development of F-refractory disease in CLL cells without the 17p deletion or TP53 mutation. The pattern of p21 and p53 expression/induction did not change with the occurrence of F-refractory disease: black represents expression without 5 Gy irradiation; gray, expression after 5 Gy irradiation. Both samples show a low baseline level and normal up-regulation of p21 and p53 after irradiation. (B) For comparison, an example of type A defect with high baseline p53 levels caused by a mutation of TP53. After induction of DNA damage, p21 is not up-regulated.$

Functional assessment of p21/p53 induction after DNA damage may be normal in cases with F-refractory disease without the 17p deletion or TP53 mutation. (A) Normal p21 and p53 induction before and after development of F-refractory disease in CLL cells without the 17p deletion or TP53 mutation. The pattern of p21 and p53 expression/induction did not change with the occurrence of F-refractory disease: black represents expression without 5 Gy irradiation; gray, expression after 5 Gy irradiation. Both samples show a low baseline level and normal up-regulation of p21 and p53 after irradiation. (B) For comparison, an example of type A defect with high baseline p53 levels caused by a mutation of TP53. After induction of DNA damage, p21 is not up-regulated.

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