ESC1 module and MYC show similar expression variation, except in normal centroblasts/centrocytes. Expression of the core ESC1 module and MYC (a component of ESC1) was mapped to independent datasets via gene symbols and compared across normal and malignant B cells. Each row represents a separate expression dataset, and the 2 columns show mean expression of ESC1 genes (left, white) and MYC (right, gray). (A-B) Variation across stages of normal B-cell development from bone marrow and tonsil samples,²²  showing high expression of ESC1 module but low expression of MYC in CBs/CCs relative to other normal B cells. (C-D) Normal (right of dotted line) and malignant (left) B-cell expression.³⁷  ESC1 module is less highly expressed in FL than in de novo DLBCL (dDLBCL) and normal CBs/CCs, whereas MYC is higher in dDLBCL than in FL or normal CBs/CCs. HSC indicates hematopoietic stem cell; EB, early B cell; ProB, Pro-B cell; PreB, Pre-B cell; ImB, immature B cell; NB, naive B cell; MB, memory B cell; CLL, chronic lymphocytic leukemia; HCL, hairy cell leukemia; MCL, mantle cell lymphoma; FL, follicular lymphoma; dDL, de novo DLBCL; PEL, primary effusion lymphoma; and BL, Burkitt lymphoma.