Three-module stemness model stratifies survival in FL and DLBCL-t and predicts transformation. A linear predictor score (LPS) based on 3 stemness modules was defined that predicted survival across FL patients in the training set.⁷  (A) Training set FL patients were split into high-risk/low-risk groups according to whether their LPS was more or less than its median value. (B) Patients with high LPS were more likely to have subsequent transformation of their FL to DLBCL-t, compared with patients with low LPS. (C-D) LPS stratified survival within FL-pt, but not within FL-nt. (E) LPS performance in validation set of 187 FL patients.¹¹  (F) Surprisingly, the LPS defined in FL also stratified patient survival when applied to DLBCL-t gene expression, despite survival times being from initial diagnosis of FL, not time of DLBCL-t biopsy.