γδ T cell–dependent elimination of DC-like cells terminates NK cell IFN-γ production induced by zoledronate. CD56⁺ PBMCs or CD56⁺CD3⁻ PBMCs (2 × 10⁶/mL) were stimulated with either IL-2 alone (100 U/mL) or with bisphosphonate (10 or 30μM) plus IL-2. On days 1 and 2, cells were stained for intracellular IFN-γ and for surface TCRVδ2 (γδ T lymphocytes). Arrows point out DC-like cells surviving in the absence but not in the presence of γδ T lymphocytes. Frames point out NK cells that terminate IFN-γ production in the presence of γδ T lymphocytes but continue to produce IFN-γ in the absence of γδ T lymphocytes. Results are representative of 3 independent experiments.