Abrogation of the zoledronate-induced NK cell IFN-γ response by prenyl pyrophosphate supplementation or cytokine neutralization. CD56⁺CD3⁻ PBMCs (1 × 10⁶/mL) solely consisting of NK cells and DC-like cells were stimulated with zoledronate (30μM) plus IL-2 (100 U/mL) in the presence or absence of prenyl pyrophosphates (FPP, GGPP), neutralizing antibodies (all IgG1), or IgG1 control antibody. One of 3 independent experiments is shown.