Figure 1
![Figure 1. Genetic analysis of the described patients. (A) Pedigree of the 2 families. (B) Histograms from the patients sequencing with indication of found mutations. (C) Localization of mutations within the factor B gene (rectangles represent exons; line represents introns) and within the protein sequence (the 3 domain types—CCP [complement control protein], VWFA [von Willebrand type A], and serine protease are indicated). Numbering is made with the first methionine referred as 1 (as described in Hourcade et al13).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/114/13/10.1182_blood-2009-01-197640/4/zh89990941170001.jpeg?Expires=1735843864&Signature=mMC72HE0fSkoqTSvMAXEIte5THj5NLxU1dEgdcDYFUC3J-9hlXPyeR7huKwqOTTvEUqKQ5yVbD-ZWlerErdVvRR9cNF4GS5A2-XAuyTlNBRrdJ9WGk1Ha2DuSJa-4iZ6lXoX3qPinmukxeia7BtSfZU2g5VA~gd0W4vwk1L3xwKbKOeUG9VlCM43G6Q3eceH4QWOkpnIAApzswIxghDPSjWlf8bv9DqohG93g6KZGoX0Ri5cIVGciCiPFqYojXTKMn3cSZcAUV4Q0bf6ELqgFX3zHnGmykOJFfADE4SZx6OHRlK8jhNlrwzJBpHHhmpWqEIDEs5QJ3ZR4ZuKdT-1sw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Genetic analysis of the described patients. (A) Pedigree of the 2 families. (B) Histograms from the patients sequencing with indication of found mutations. (C) Localization of mutations within the factor B gene (rectangles represent exons; line represents introns) and within the protein sequence (the 3 domain types—CCP [complement control protein], VWFA [von Willebrand type A], and serine protease are indicated). Numbering is made with the first methionine referred as 1 (as described in Hourcade et al13 ).
