Ex vivo femural pQCT analyses of ADA^+/+ and ADA^−/− compared with Rag2γc^+/+ and Rag2γc^−/− mice. (A) Total area (mg/cm³). (B) Medullary canal area (mm²). (C) Cortical thickness (mm). (D) Canal area/total area ratio (AU). (E) Strength-strain index (mm³). (F) Schematic view representing cross-sectional bone sections in diaphysis of all 4 groups of mice analyzed. (G) Cortical density (mm/cm³). (H) Trabecular density (mm/cm³). Box and whiskers graphs. ***P < .001. **P < .001-.005. *P = .005-.05. ADA^+/+ (n = 22), ADA^−/− (n = 18), Rag2γc^+/+ (n = 10), and Rag2γc^−/− (n = 14).