Rescue of the ADA bone phenotype by ERT, GT, or BMT. Comparable serum levels of (A) RANKL (ng/mL), (B) OPG (ng/mL), *P = .005-.05; **P = .001-.005. (C) RANKL/OPG ratio (AU), (D) PINP (ng/mL), and (E) CTX (ng/mL) at 12 weeks of age. Scatter plots plus average. PEG-ADA (n = 7), GT (n > 4), BMT (n = 10), and wild-type controls (n = 7). (F) Strength-strain index (mm³); average ± SD; PEG-ADA (n = 4), GT (n = 5), BMT (n = 5), and wild-type controls (n = 4).