Effect of r-hu ADAMTS13 infusion on intracerebral hemorrhage after stroke in thrombocytopenic mice and mice with normal platelet count. (A) Supernatants of right (injured) hemisphere homogenates. (B) Hemorrhage volume as determined by hemoglobin brain tissue analysis. Hemoglobin level (corresponding to a volume of blood in μL) was determined in the right infarcted hemisphere. The levels of hemoglobin from the right hemispheres with normal platelet count were low (the same as in the noninjured left hemispheres whether platelet depleted or not depleted; not shown). In contrast, hemorrhage was significant in the right hemispheres of platelet-depleted mice. Infusion of r-hu ADAMTS13 did not affect the hemorrhage volume.