Direct control of Jmjd3 induction by STAT6. (A) The structure of mouse Jmjd3 gene (NM_001017426). Small boxes represent untranslated regions; larger boxes, coding regions. The putative STAT6-binding sites (regions 1-5) and their sequences are shown. MF-TSS indicates macrophages-transcriptional start site.²⁸  (B) Anti-STAT6 ChIP assay was performed with primers surrounding STAT6-binding site–containing regions of Jmjd3 gene in BMDMs after IL-4 stimulation. Data are representative of 3 independent experiments and are expressed as mean ± SEM. *P < .05, ***P < .001, compared with IgG control.