β-catenin affects expression of target genes in patient sample tissue microarrays. (A) IHC analysis on patient sample tissue microarrays show that AurKA and CDC25B reflect increased β-catenin expression from MGUS to MM compared with normal BM. Costaining of β-catenin (red) and AurKA (brown) in top right panel inset. (B) Immunoblot analysis of AurKA expression normal plasma cells (PC) and MM primary tumors compared with β-catenin expression. Note a correlation between β-catenin and AurKA expression in patient samples 1, 2, 5, and 6.