Identification of pathologic NK-cell subset in HIV-1 infection by the distribution on the cell surface of CD56 and Siglec-7. (A) Flow cytometric dot plot graphs showing the distribution of fresh Siglec-7+/CD56+ (green), Siglec-7−/CD56+ (blue), and Siglec-7−/CD56− (red) NK-cell subsets from a representative healthy donor (first column), early viremic (second column), chronic viremic (third column), and LTNP (fourth column) HIV-1–infected patient. (B) Statistical summary graphs of dot plot with medians (horizontal black bars) and P values showing the frequencies of fresh Siglec-7+/CD56+ (green), Siglec-7−/CD56+ (blue), and Siglec-7−/CD56− NK-cell subsets from healthy donors compared with those of HIV-1–infected persons at different stages of disease.