Figure 1
Figure 1. Schematic diagrams of 20-2b and its constituent DNL modules. Expression cassettes and structures of (A) CH3-AD2-IgG, (B) IFN-α2b-DDD2, and (C) 20-2b. Blue helix represents DDD2; red helix, AD2; SH indicates sulfhydryl groups of engineered cysteines; V, variable (green); C, constant (gray); G, hinge; L, linker (GSGGGGSGG); HL, 6-His/linker, HL (EKSHHHHHHGSGGGGSGGG). CH3-AD2-IgG-v-mab, CH3-AD2-IgG-e-mab, CH3-AD2-IgG-734, and CH3-AD2-IgG-hR1 modules (A) were used to generate 20-2b, 22-2b, 734-2b, and 1R-2b, respectively.

Schematic diagrams of 20-2b and its constituent DNL modules. Expression cassettes and structures of (A) CH3-AD2-IgG, (B) IFN-α2b-DDD2, and (C) 20-2b. Blue helix represents DDD2; red helix, AD2; SH indicates sulfhydryl groups of engineered cysteines; V, variable (green); C, constant (gray); G, hinge; L, linker (GSGGGGSGG); HL, 6-His/linker, HL (EKSHHHHHHGSGGGGSGGG). CH3-AD2-IgG-v-mab, CH3-AD2-IgG-e-mab, CH3-AD2-IgG-734, and CH3-AD2-IgG-hR1 modules (A) were used to generate 20-2b, 22-2b, 734-2b, and 1R-2b, respectively.

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