Figure 7
Mer inhibition significantly delays the onset of disease and improves leukemia-free survival in a mouse xenograft model of human leukemia. (A) Sub-lethally irradiated NOD-SCID mice (10-26 animals per group) were injected with 5 × 106 cells of the indicated cell lines. (B) Nonirradiated NOD-SCID mice (5-8 animals per group) were injected with 5 × 105 cells of the indicated cell lines. Ticks on the Kaplan-Meier survival curves indicate censored subjects (mice for which samples could not be obtained or did not have leukemia at time of death). Comparison of survival curves revealed a significant difference in leukemia-free survival with Mer inhibition (wild-type or shControl vs shMer1A or shMer1B, log-rank test).
