Progression-free survival and overall survival in patients with respect to VH4-34 status and variant phenotype. (A-B) Progression-free survival; (C-F) overall survival. Median values are listed in Table 5. Panels C and D show data for all 82 patients with respect to VH4-34 (C) or variant (D) status, whereas panel E includes only classic HCL and panel F only VH4-34⁻ patients.