Model for the role of GATA-1 and VDR in myeloid DC subset generation at steady state versus inflammatory conditions. VDR is induced downstream of TGF-β1 during LC differentiation. In contrast, DCs derived from monocytes in response to IL-4 down-regulate VDR. IL-4 induces GATA-1, which in turn represses VDR. Our study showed that VDR and GATA-1 are functionally involved in myeloid DC subset differentiation.