Figure 7
Figure 7. Effect of mAbp1 on the high-affinity conformation of β2 integrins under flow conditions. (A) Confocal microscopy images of mAbp1+/+ and mAbp1−/− PMNs adherent on immobilized ICAM-1 on stimulation with 1μM fMLP stained for CD18. Box whisker blots of numbers of clusters of CD18 clusters in all 3 conformations (CD18) (B-C,E) or CD18 clusters in the high-affinity conformation (mAb24) (D,F), under static (B-D) or flow (E-F) conditions (0.5 dyne/cm2). Median numbers are indicated; n = 3.

Effect of mAbp1 on the high-affinity conformation of β2 integrins under flow conditions. (A) Confocal microscopy images of mAbp1+/+ and mAbp1−/− PMNs adherent on immobilized ICAM-1 on stimulation with 1μM fMLP stained for CD18. Box whisker blots of numbers of clusters of CD18 clusters in all 3 conformations (CD18) (B-C,E) or CD18 clusters in the high-affinity conformation (mAb24) (D,F), under static (B-D) or flow (E-F) conditions (0.5 dyne/cm2). Median numbers are indicated; n = 3.

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