Multiclass analysis of gene expression in normal persons, sMDS, and tMDS. Comparison of concordantly expressed genes, which were increased more than or equal to 1.5-fold in sMDS versus normal and a further more than or equal to 1.5-fold increment in tMDS versus sMDS demonstrated 26 differentially overexpressed genes to be highly significantly associated with potential for disease progression (FDR = 1%).