Schematic of the potential roles of TGFBIp in arterial thrombosis. Platelets adhere to the damaged vascular wall by a variety of mechanisms that may include interactions between the FAS1 domain of TGFBIp and integrin α₅β₁. The RGD-domain of TGFBIp may also contribute to platelet spreading via interactions with integrin α_IIbβ₃. As platelet agonists are generated at the site of injury, they induce release of TGFBIp from stored pools, which in turn activates other platelets and promotes thrombus formation.