Survival analysis of patients with newly diagnosed MM who received Len-Dex as initial therapy. (A) PFS by risk stratification; median PFS is 18.5 months for high-risk versus 36.5 months for standard-risk patients (P < .001). (B) OS by risk stratification (high-risk vs standard-risk patient); median OS not reached (P = not significant). (C) PFS of strictly categorized patients (N = 55) who either had all the 3 tests (metaphase cytogenetics, fluorescence in situ hybridization [FISH], and PCLI) or at least 1 test that led to their inclusion in the high-risk group; median PFS = 18.5 months for the high-risk group and 36.5 months for the standard-risk group (P < .001). (D) OS of strictly categorized patients (N = 55) who either had all the 3 tests (cytogenetics, FISH, and PCLI) or at least 1 test that led to their inclusion in the high-risk group; median OS not reached for either high-risk or standard-risk group.