Cumulative incidence for cGVHD based on pretransplantation MICA Abs using different cutoffs. Relationship between pretransplantation MICA Abs, sMICA serum level, and cGVHD. (A-B) Patients having the lower titer of pretransplantation MICA Abs are those at high risk of cGVHD whatever the cutoff values, ie, 2 or 3 (univariate analysis). (C) Nonparametric testing showed an inverse relationship between MICA Abs and sMICA levels (values > 3 correlates with serum levels < 80 pg/mL). (D) The lower risk for cGVHD was noted in patients with MICA Abs greater than 3 and sMICA less than 80 pg/mL, whereas the highest was in those having MICA Abs less than 3 with sMICA greater than 80 pg/mL (univariate analysis). Of note, the patient group with MICA Abs greater than 3 and sMICA greater than 80 pg/mL is not represented in the figure because of the low number of patients (n = 3).