Human platelets issued from CD34⁺-progenitor cells incorporate into NOD/SCID mouse thrombi. (A-D) Representative images of murine/human thrombi from CD34⁺-transplanted NOD/SCID mouse-anticoagulated PB incubated without (A) or with 10 μg/mL moAbs 6B4 (B), 16N7C2 (C), or 6B4 + 16N7C2 (D, 10 μg/mL each) after 2 minutes of perfusion over collagen-coated coverslips (200 μg/mL) at 1500 seconds⁻¹. Human platelets, representing 2.1% of the total platelet population, and murine platelets were stained with anti–human CD61-PE and anti–mouse CD42c-Alexa 488, respectively. (E) PB from nontransplanted mouse. (F) Surface coverage by human platelets from untreated, transplanted NOD/SCID PB was calculated at the end of each perfusion experiment and compared with the same transplanted NOD/SCID PB incubated with moAbs. Data represent mean values ± SEM (n ≥ 3 for each group). Statistical analysis was performed using paired Student t test (**.001 < P < .05).