Binding of Hp and Hpr to Hb and uptake of the complexes by the trypanosomal receptor. Complexes of Hp-Hb and Hpr/TLF1-Hb bind to, and are internalized by, the TbHpHbR positioned on the trypanosome surface. On internalization, the heme moiety liberated from Hb is incorporated into hemoproteins of the parasite. The internalized TLF1 component apoL-I creates pores in the lysosomal membrane, thus leading to influx of chloride ions, osmotic swelling of the lysosome, and, ultimately, lysis of the parasite.