G^bG mice that underwent transplantation after myeloablative conditioning, which resulted in correction of hematologic parameters that correlated with the HbF expression. There was sustained reduction in reticulocytes (A), and increase in hematocrit (B) and RBC numbers (C) over time. (D) Leukocytosis decreased with normalization of WBC counts. Data shown represent mean (± SEM) values of G^bG mice (n = 5; ●) and mice that underwent mock transplantation (n = 10; ○). ☆ represents mean values in BERK mice that were HSC donors for the G^bG and mock transplantations. (E-G) Decrease in reticulocytes, and increased hematocrit and RBC numbers correlated with the proportion of F cells in individual mice. (H) WBC counts decreased but normalized when the F cells exceeded 60%. WBC counts, counted on an automated analyzer, were representative of circulating leukocytes, since only occasional nucleated RBCs were seen in peripheral smears. Each data point/symbol in panels E-H represents one G^bG mouse and symbols for individual mice have been kept consistent, to trace individual mice in Figures 1 and 2. ☆ represents mean values in BERK mice that were HSC donors for the G^bG and mock transplantations.