Correction of organ pathology in G^bG≥10 mice that underwent transplantation after reduced-intensity conditioning and improved overall survival. (A) Representative hematoxylin-eosin–stained sections of a kidney, liver, and spleen of G^bG≥10 and G^bG<10 mice 48 to 50 weeks after reduced-intensity conditioning transplantation and a 3-month-old BERK control. Image acquisition information is available in supplemental data. (B) Kaplan-Meier survival curve showed significantly improved survival of the G^bG≥10 mice compared with mock/G^bG<10 mice at 50 weeks. Survival at 24 weeks is denoted by a dashed vertical line to compare with survival of the G^bG mice in the myeloablative transplantation model (supplemental Figure 3c).