Expression of different c-FLIP short isoforms in mammals. (A) Sequence alignment of mammalian c-FLIPS and c-FLIPR proteins. Alignments were performed using Geneious software (http://www.geneious.com). Sequences are shown in single-letter amino acid code. (B) Analysis of c-FLIP genomic sequences of selected cell lines by sequencing of genomic DNA. Shown is the region encompassing the 3′ splice site of intron 6. The AG dinucleotide consensus (bold letters) and the position of rs10190751 A/G (arrow) are indicated. (C) Distribution of the variants of rs10190751 A/G in the different populations analyzed in the HapMap project (CEU indicates Utah residents with ancestry from northern and western Europe; HCB, Han Chinese in Beijing, China; JPT, Japanese in Tokyo, Japan; and YRI, Yoruba in Ibadan, Nigeria).
