Reciprocal patterns of PTPROt and BCL6 expression in normal B cells and primary DLBCLs. (A) Relative BCL6 and PTPROt transcript abundance in 2 independent series of highly purified normal B cells (naive, GC centroblasts [CB] and centrocytes [CC], memory). (B) Relative BCL6 and PTPROt transcript abundance in 176 newly diagnosed and previously profiled DLBCLs.¹⁴  Normal GC B cells that were profiled at the same¹⁴  time were included for comparison (left). Comprehensive cluster designations for the primary DLBCLs and normal GC cells are indicated above the heat map. The primary DLBCL series includes 77 BCR, 50 OxPhos and 49 HR tumors. Color scale at bottom indicates relative expression and SDs from the mean. Red connotes high-level expression; blue indicates low-level expression