Identification of RARα2-associated signals. (A) Heat maps of the 96 differentially expressed genes in RARα2⁻ (n = 54) and RARα2⁺ (n = 26) MM cell samples from the 80 patients. Gene symbols are plotted at the right side, and samples are plotted along the top horizontal axis. Red indicates up-regulation; and blue indicates down-regulation. (B) Western blots examined pSTAT3 and STAT3 and p-RK and ERK in RARα2-overexpressing (R2) cells of ARP.1, OCI-MY5, and XG1 cells. Wild-type (WT) and EV cells were used as controls. β-actin was used as loading control. Shown are the representative results of 3 independent experiments.