MAPCs affect costimulatory molecule expression on T cells and DCs in the spleen. FACS analysis of spleen cells harvested from transplanted mice on day 4 was performed to determine the percentage of CD4⁺ (A), CD8⁺ (B), and CD11c⁺ (C) cells that expressed the indicated costimulatory molecules. In this transplant, MAPCs were untreated or pretreated with indomethacin, as described, before their application.